Beim zervikalen CUP-Syndrom liegt eine histologisch gesicherte Halslymphknotenmetastase
bei unbekanntem Primärtumor vor. Die Diagnostik beinhaltet neben Anamnese, klinischer
Untersuchung und histologischer Sicherung die radiologische Bildgebung mittels PET/CT
sowie eine Panendoskopie mit histologischer Primärtumorsuche. Als Behandlungsoptionen
stehen eine chirurgische Therapie mit Neck Dissection und die Radiochemotherapie zur
Verfügung.
Abstract
In CUP syndrome (CUP = cancer of unknown primary) there are 1 or more metastases of
a primary tumor that cannot be localized despite extensive diagnostics. CUP syndrome
accounts for 5% of all human malignancies, making it one of the 10 most common forms
of cancer. In addition to inflammatory lymph node enlargement and benign changes such
as cervical cysts, lymph node metastases are among the most common cervical masses.
Cervical CUP syndrome is a histologically confirmed cervical lymph node metastasis
with an unknown primary tumor. In addition to anamnesis, clinical examination and
histological confirmation, diagnostics include radiological imaging using PET-CT and
panendoscopy with histological primary tumor search. Treatment options include surgical
therapy with neck dissection and chemoradiotherapy.
Schlüsselwörter
Kopf-Hals-Tumore - Metastase - CUP-Syndrom - Primärtumorsuche - Neck Dissection -
Bestrahlung - Radiochemotherapie
Keywords
Head neck tumors - metastasis - CUP-Syndrom - cancer of unknown primary - neck dissection
- chemoradiotherapy
